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Disadvantage is a 12 letter word which starts with the letter D and ends with the letter E for which we found 3 definitions.

(n.) Deprivation of advantage; unfavorable or prejudicial quality condition circumstance or the like; that which hinders success or causes loss or injury.
(n.) Loss; detriment; hindrance; prejudice to interest fame credit profit or other good.
(v. t.) To injure the interest of; to be detrimental to.
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