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Insignificance is a 14 letter word which starts with the letter I and ends with the letter E for which we found 3 definitions.

(n.) The condition or quality of being insignificant; want of significance sense or meaning; as the insignificance of words or phrases.
(n.) Want of force or effect; unimportance; pettiness; inefficacy; as the insignificance of human art.
(n.) Want of claim to consideration or notice; want of influence or standing; meanness.
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