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Irritability is a 12 letter word which starts with the letter I and ends with the letter Y for which we found 3 definitions.

(n.) The state or quality of being irritable; quick excitability; petulance; fretfulness; as irritability of temper.
(n.) A natural susceptibility characteristic of all living organisms tissues and cells to the influence of certain stimuli response being manifested in a variety of ways -- as that quality in plants by which they exhibit motion under suitable stimulation; esp. the property which living muscle processes of responding either to a direct stimulus of its substance or to the stimulating influence of its nerve fibers the response being indicated by a change of form or contraction; contractility.
(n.) A condition of morbid excitability of an organ or part of the body; undue susceptibility to the influence of stimuli. See Irritation n.3
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