pain

cause emotional anguish or make miserable

“It pains me to see my children not being taught well in school”

a symptom of some physical hurt or disorder

“the patient developed severe pain and distension”

cause bodily suffering to and make sick or indisposed

emotional distress; a fundamental feeling that people try to avoid

“the pain of loneliness”

a somatic sensation of acute discomfort

“as the intensity increased the sensation changed from tickle to pain”

something or someone that causes trouble; a source of unhappiness

a bothersome annoying person

“that kid is a terrible pain”