plague

any epidemic disease with a high death rate

cause to suffer a blight

a swarm of insects that attack plants

“a plague of grasshoppers”

annoy continually or chronically

a serious (sometimes fatal) infection of rodents caused by Yersinia pestis and accidentally transmitted to humans by the bite of a flea that has bitten an infected animal

an annoyance

“those children are a damn plague”

any large scale calamity (especially when thought to be sent by God)