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Ache is a 4 letter word which starts with the letter A and ends with the letter E for which we found 3 definitions.

n. A name given to several species of plants; as, smallage, wild celery, parsley.
v. i. Continued pain, as distinguished from sudden twinges, or spasmodic pain. "Such an ache in my bones."
v. i. To suffer pain; to have, or be in, pain, or in continued pain; to be distressed.

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