bitter

the taste experience when quinine or coffee is taken into the mouth

make bitter

proceeding from or exhibiting great hostility or animosity

“a bitter struggle”

very difficult to accept or bear

“the bitter truth”

causing a sharply painful or stinging sensation; used especially of cold

“bitter cold”

harsh or corrosive in tone

“bitter words”

the property of having a harsh unpleasant taste

extremely and sharply

“it was bitterly cold”

marked by strong resentment or cynicism

“bitter about the divorce”

causing a sharp and acrid taste experience

“quinine is bitter”

English term for a dry sharp-tasting ale with strong flavor of hops (usually on draft)

expressive of severe grief or regret

“shed bitter tears”