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Spline is a 6 letter word which starts with the letter S and ends with the letter E for which we found 2 definitions.

(n.) A rectangular piece fitting grooves like key seats in a hub and a shaft so that while the one may slide endwise on the other both must revolve together; a feather; also sometimes a groove to receive such a rectangular piece.
(n.) A long flexble piece of wood sometimes used as a ruler.
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